Bioidentical pregnenolone in liquid form

Pregnenolone (30 ml)


Promote hormone balance and adrenal health with plant-derived bioidentical pregnenolone. BioMatrix’ liquid formula provides the most effective oral delivery method available for bioidentical hormone replacement therapy (BHRT).

  • Defend against age-related decline in hormones like DHEA, testosterone, and progesterone
  • Contains micronized oral pregnenolone extracted from Diosgenin (wild yam), for maximum absorption and efficacy
  • Boost mood and cognitive performance by supporting brain hormone function
  • Strengthen the HPA axis stress response and promote anti-aging

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Suggested Use

Take 2 drops 2 times daily or as recommended by your health care professional.


Two Drops of Pregnenolone Contain:

Pregnenolone – 2.4 mg

Other Ingredients: Glycerin and Alcohol

Allergen Information

Contains: No known allergens

Formulated to be free of: Egg, Dairy, Shellfish/Fish, Tree Nuts/Peanuts, Soy, Gluten, Bromelain, Corn, Artificial Colors, Artificial Flavors, Artificial Preservatives, Sodium, Sugar, Rice.

Pregnenolone for Stress Relief

Produced primarily in the adrenal glands, pregnenolone is the precursor to all steroidal hormones, notably testosterone, progesterone, cortisol, estrogens, and DHEA. While produced naturally in the body, it is often taken as a supplement in adrenal fatigue and anti-aging protocols.
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Pregnenolone has numerous health benefits such as enhancing memory and managing stress-related fatigue. When the adrenal glands are tired, pregnenolone levels drop, which can lead to a decline in most of the hormones that maintain your health.

Bioidentical Pregnenolone Liquid for BHRT

Its role as the mother of all steroidal hormones is at the core of its impact on vitality and resistance to illness. By taking bioidentical pregnenolone, as well as other hormone-therapy products such as licorice root extract and DHEA, many symptoms of ill health can be avoided, and physical and cognitive health restored.

The BioMatrix Pregnenolone Advantage

BioMatrix Pregnenolone is derived from an extraction of the steroidal backbone of the Diosgenin yam (Dioscorea villosa). Once ingested, the body cannot tell the difference because this exogenous form and the one it produces endogenously (within the body). Our liquid pregnenolone has an absorption rate much higher than pill or tablet forms.

With BioMatrix Pregnenolone, the ability to deliver precise dosages is unparalleled. With 1.2 mg of pregnenolone per drop, it is easy to manage the number of drops and enjoy flexibility in your maintenance or intervention therapies. And there is no mystery as to whether or not you are absorbing the active ingredients. It happens almost instantly, in the mouth.

The Formula: Purpose

  • Pregnenolone – An endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones. In addition, pregnenolone is biologically active in its own right, acting as a neurosteroid. Its numerous benefits as a supplement include improved mental health, cognition, mood, energy, metabolism, and nervous system function.
  • Glycerin – To preserve the pregnenolone’s stability and maximize potency through antimicrobial properties. The glycerin is sourced from sustainable palm oil.
  • Alcohol – To act as a base carrier for the pregnenolone so it can be efficiently delivered through the oral cavity’s barrier.

FAQ: Pregnenolone

How do I take this product?

While BioMatrix cannot instruct customers how to use these products due to FDA regulations, Pregnenolone is designed to be taken orally. Keep the product in your mouth as long as possible. If sensitive to alcohol, put the drops in a spoon with some olive or coconut oil (or similar), and swish around in your mouth.

When should I take this product?

Timing of hormone delivery is not something BioMatrix can advise on. It is best to work with a health professional experienced in BHRT, and ideally involving lab tests to dial in the precision of the treatment. And then many nuances between delivery methods; oral pellets, creams, pills, oils, etc.

What is the Alcohol content?

About 60%

How many drops per bottle?

Approximately 1,000

How many mg of the hormone in 1 drop?

1.2 mg per drop

What is this derived from?

BioMatrix pregnenolone is derived from an extraction of the steroidal backbone of the Diosgenin yam (Dioscorea villosa). This exogenous form of pregnenolone is molecularly identical to that which the body produces.

What is the alcohol derived from

Corn, however, there is no corn antigen. It just comes from a corn source. In the production of alcohol, the starch fraction of the grain is converted to fermentable sugar. The fermentable sugar is in turn converted to alcohol. The alcohol is further purified through distillation. Proteins and other grain derivatives are separated and removed from the Ethyl Alcohol.

What is the glycerin derived from?

Certified Sustainable Palm Oil (CSPO)

The Formula: Science-Based Ingredients

Pregnenolone is a cholesterol-derived hormone precursor that plays a critical role in overall health. It promotes the healthy performance of the hypothalamic-pituitary-adrenal axis (HPAA) by producing the hormones that interact with the brain to regulate function.

  • Stress Response – By repleting your adrenals with the starting block for steroid hormone synthesis, pregnenolone helps enhance the function of your HPAA, which facilitates your stress response. Multiple studies show that patients who supplemented with pregnenolone experienced significantly enhanced states of calm [1,2].
  • Memory and Cognitive Performance – Since pregnenolone is a parent hormone within the neurosteroid family, it supports acetylcholine function in various areas of your brain. Studies show that patients who supplemented with pregnenolone experienced significantly improved attention, executive function, and spatial working memory [3].
  • Mood – Studies show that participants with low mood who supplemented with pregnenolone for 12 weeks experienced significantly increased remission rates in depressive symptoms [4]. At the neurocircuitry level, a randomized controlled trial found that participants who supplemented with pregnenolone experienced significantly improved anxiety symptoms, likely due to enhanced connectivity between the amygdala and dorsal medial prefrontal cortex [5].
  • Sleep – Pregnenolone is a neurosteroid that can cross your blood-brain barrier, accumulating in your central nervous system during periods of sleep. Once pregnenolone and its derivatives reach the brain, it alters the sleep-wake cycle by communicating with the main sleep hormone, melatonin. By supporting melatonin function, pregnenolone may target healthy sleep patterns.
  • Libido – Pregnenolone directly supports your production of DHEA, testosterone, and estradiol by stimulating your adrenal hormone cascade. All three of these hormones play an integral role in libido and sexual performance. Pregnenolone supplementation may be advantageous since numerous studies show that supplementing with these three hormones significantly improves libido [6,7].
  • Musculoskeletal Pain – By supporting the production of testosterone and estradiol, pregnenolone may support joint and bone health. One randomized, double-blind, placebo-controlled clinical trial found that participants who supplemented with pregnenolone for four weeks experienced significantly improved lumbar back pain [8].
  • Cholesterol Levels – Since pregnenolone uses cholesterol to create other steroid hormones, like testosterone, pregnenolone may support and maintain healthy cholesterol levels. Studies show that patients who supplemented with hormone replacement therapy exhibited significantly improved total cholesterol and non-HDL levels [9].


  1. Söderpalm AH, Lindsey S, Purdy RH, Hauger R, Wit de H. Administration of progesterone produces mild sedative-like effects in men and women. Psychoneuroendocrinology. 2004;29(3):339-354. doi:10.1016/s0306-4530(03)00033-7
  2. Timby E, Balgård M, Nyberg S, et al. Pharmacokinetic and behavioral effects of allopregnanolone in healthy women. Psychopharmacology (Berl). 2006;186(3):414-424. doi:10.1007/s00213-005-0148-7
  3. Kreinin A, Bawakny N, Ritsner MS. Adjunctive Pregnenolone Ameliorates the Cognitive Deficits in Recent-Onset Schizophrenia: An 8-Week, Randomized, Double-Blind, Placebo-Controlled Trial. Clin Schizophr Relat Psychoses. 2017;10(4):201-210. doi:10.3371/CSRP.KRBA.013114
  4. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology. 2014;39(12):2867-2873. doi:10.1038/npp.2014.138
  5. Sripada RK, Marx CE, King AP, Rampton JC, Ho SS, Liberzon I. Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits. Biol Psychiatry. 2013;73(11):1045-1053. doi:10.1016/j.biopsych.2012.12.008
  6. Corona G, Isidori AM, Buvat J, et al. Testosterone supplementation and sexual function: a meta-analysis study. J Sex Med. 2014;11(6):1577-1592. doi:10.1111/jsm.12536
  7. El-Sakka AI. Dehydroepiandrosterone and Erectile Function: A Review. World J Mens Health. 2018;36(3):183-191. doi:10.5534/wjmh.180005
  8. Naylor JC, Kilts JD, Shampine LJ, et al. Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial. JAMA Netw Open. 2020;3(3):e200287. Published 2020 Mar 2. doi:10.1001/jamanetworkopen.2020.0287
  9. Crespo CJ, Smit E, Snelling A, Sempos CT, Andersen RE; NHANES III. Hormone replacement therapy and its relationship to lipid and glucose metabolism in diabetic and nondiabetic postmenopausal women: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2002;25(10):1675-1680. doi:10.2337/diacare.25.10.1675


In order to deliver these nutrients to create benefits, there must be efficient absorption into the cells.


Our formulas contain ingredients and co-factors which support the ability of nutrients to do work quickly.


We use botanically sourced ingredients whenever possible, to provide your body with nature’s simplicity and efficacy.