Adapt Align (60 Caps)

Why was the Adapt Align formula changed in 2024?

After research including  consultation with well-established partner clinics who have been using adaptogens heavily for years, we have made a strategic decision to remove Bacopa from the formula. While Bacopa offers some nootropic benefits, its effects have been inconsistent in studies, and it has not resonated as strongly with our users compared to the other core ingredients.

In place of Bacopa, we have increased the quantities of Ashwagandha (from 250 mg to 400 mg per serving) and Rhodiola (from 200 mg to 300 mg per serving). This adjustment enhances the formula’s foundational support of the stress response. Additionally, we have introduced 20 mg of Black Pepper extract (Piperine) per serving, to maximize the bioavailability of the Ashwagandha, further boosting the efficacy of Adapt Align. Piperine also has neuroprotective properties.

We are also announcing a new price created to give you better value. The price of Adapt Align is moving from $48.50 to $42.00.

What are adaptogens and how do they help?

Adaptogens are a group of plants and herbs that are said to help the body resist various stressors, including physical, chemical, and biological stresses. Originally conceptualized in the 1940s by Soviet scientist Nikolai Lazarev, adaptogens are thought to enhance the body’s ability to maintain balance or homeostasis during stress by modulating the production and regulation of hormones. They particularly affect the hypothalamic-pituitary-adrenal (HPA) axis, which is crucial in the body’s stress response system, helping to stabilize physiological processes.

The proposed benefits of adaptogens include modulation of the body’s stress response, potentially preventing overreactions or underreactions to stress, anti-fatigue effects that increase energy levels and reduce fatigue, and improved mental functions such as concentration, memory, and alertness. By influencing energy production mechanisms and cognitive functions, adaptogens can enhance both mental performance and physical endurance, particularly in stressful situations.

Can I take this with Support Adrenals?

Combining Adapt Align with Support Adrenals is encouraged, especially if you have adrenal fatigue or chronic HPA axis dysfunction.

How long does it take to notice the effects?

The cognitive benefits of this formula are generally realized within 30-60 minutes.

Why is ashwagandha so popular? What does it do?

Ashwagandha has become increasingly popular due to its status as a widely researched (and effective) adaptogen, a natural substance believed to help the body cope with stress. Studies indicate that it can effectively reduce overall stress and anxiety in individuals. This is particularly significant as it offers a natural alternative for managing these conditions.

In addition to its stress-relief properties, ashwagandha is also recognized for its benefits in enhancing brain health and cognitive function. It has been shown to improve memory, reaction time, and task performance, attributed to its antioxidant properties that help protect nerve cells from harmful free radicals.

• Ashwagandha Root Extract – Ashwagandha has been used as a tonic within Ayurvedic medicine for millennia to support energy and mental focus. Ashwagandha is an adaptogen and is rich in withanolides, which helps to balance cortisol levels. Through this role, Ashwagandha supports stress reduction and helps to defend against insomnia [1]. Additionally, this extract may support cognitive function by enhancing reaction time and task performance [2].
• Rhodiola rosea Root Extract – Rhodiola is an adaptogen that contains potent rosavins that impact cognitive health. Through its adaptogenic roles, Rhodiola may support stress tolerance, energy levels, attention, and mood [3,4]. Rhodiola promotes a positive mood by balancing levels of key neurotransmitters, such as serotonin [5].
• Eleuthero Root Extract – Also known as Siberian ginseng, this extract has been used within traditional Chinese medicine for its ability to support cognitive health. Rich in eleutherosides, Eleuthero is an adaptogen that enhances your body’s stress tolerance by targeting cortisol levels. This extract is also used to support higher social functioning [6].
• L-Theanine – This amino acid is found within black and green tea and is known for its neuroprotective properties. L-theanine supports stress defense and promotes cognitive function by enhancing accuracy and alertness [7,8]. Suntheanine®, an improved form of L-theanine, helps to further promote relaxation by increasing alpha wave activity, without drowsiness. By promoting a calm state, Suntheanine® supports mood and sleep quality [9].
• Phosphatidylserine (from sunflower seed) – This vital phospholipid is found within the cell membrane of every brain cell (neuron). By supporting sugar utilization, phosphatidylserine may support processing speed, memory, and attention [10].
• Black Pepper Extract – Black pepper, particularly its active compound piperine, enhances the absorption of important nutrients like selenium, curcumin, and ashwagandha [11]. Piperine has been shown to improve neurotransmission of serotonin and dopamine, which can enhance mood and cognitive function. Piperine can help improve memory and cognitive function due to its neuroprotective properties. [12]

References

1. Pingali U, Pilli R, Fatima N. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants. Pharmacognosy Res. 2014;6(1):12-18. doi:10.4103/0974-8490.122912
2. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022
3. Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009;75(2):105-112. doi:10.1055/s-0028-1088346
4. Cropley M, Banks AP, Boyle J. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytother Res. 2015;29(12):1934-1939. doi:10.1002/ptr.5486
5. Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression [published correction appears in Nord J Psychiatry. 2007;61(6):503]. Nord J Psychiatry. 2007;61(5):343-348. doi:10.1080/08039480701643290
6. Hidese S, Ogawa S, Ota M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11(10):2362. Published 2019 Oct 3. doi:10.3390/nu11102362
7. Giesbrecht T, Rycroft JA, Rowson MJ, De Bruin EA. The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci. 2010;13(6):283-290. doi:10.1179/147683010X12611460764840
8. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-354.
9. Cicero AF, Derosa G, Brillante R, Bernardi R, Nascetti S, Gaddi A. Effects of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life: a randomized clinical trial. Arch Gerontol Geriatr Suppl. 2004;(9):69-73. doi:10.1016/j.archger.2004.04.012
10. Parker AG, Gordon J, Thornton A, et al. The effects of IQPLUS Focus on cognitive function, mood, and endocrine response before and following acute exercise. J Int Soc Sports Nutr. 2011;8:16. Published 2011 Oct 21. doi:10.1186/1550-2783-8-16
11. Atal N, Bedi KL. Bioenhancers: Revolutionary concept to market. J Ayurveda Integr Med. 2010 Apr;1(2):96-9. doi: 10.4103/0975-9476.65073. PMID: 21836795; PMCID: PMC3151395.
12. Yadav, S. S., Singh, M. K., Hussain, S., Dwivedi, P., Khattri, S., & Singh, K. (2023). Therapeutic spectrum of piperine for clinical practice: a scoping review. Critical Reviews in Food Science and Nutrition, 63, 5813–5840.