Candid-X (90 Caps)

When should I take this product?

Empty stomach seems well tolerated by most people, whenever is convenient. Sensitive individuals can combine with a small, light snack.

Does this product help with Candida?

The ingredients are known to help in the suppression of Candida yeast. But each person’s Candida overgrowth is different, and in some cases, medicine is necessary. We have many clinicians who use this formula to clear up gut imbalances.

Is this an anti-fungal?

It may possess anti-fungal properties; however FDA regulations forbid us from stating specifically. We encourage you to research the individual ingredients for their active properties.

I am taking this product to deal with yeast overgrowth. Can I take it with Microb-Defend?

This combo is commonly taken by patients on a 30-60 day Candida treatment and can be very effective, but we suggest starting slowly, one product at a time, given the die-off effects that can be stimulated as dying yeast release toxins.

Can I open the capsules and pour the powder into food or drinks?

This is not recommended, because you want the capsule to break up while in the stomach for optimal release into the intestines.

• Sodium caprylate – This compound is a derivative of the caprylic acid found within coconut oil. Caprylic acid can enter the Candida cell membrane, induce rupture, and result in the functional destruction of Candida Multiple in silico and in vitro studies have found that the addition of caprylic acid disrupts the cell membrane and significantly increased Candida albicans eradication rates in biofilms [1,2]. Additionally, caprylic acid was found to significantly reduce inflammatory markers in patients with inflammatory gastrointestinal conditions [3].
• Berberine HCL – Research shows that berberine extract has substantial antimicrobial activity against a range of pathogens that include bacteria, viruses, protozoa, fungi, and yeasts (4). Berberine is highly effective against Candida in numerous studies. [5].
• Oregano (aerial part) – Native to Mediterranean regions, this herb contains bioactive compounds called carvacrol and thymol. An in vitro study found that these active compounds exhibited a dose-dependent effect that significantly inhibited the growth of Candida, and even completely inhibited growth at 0.25 mg/ml [6].
• Cinnamon (bark extract) – Cinnamon is a well-known natural fungicide. A randomized controlled trial found that cinnamon significantly and potently inhibited over three strains of Candida, including Candida albicans [7]. Another randomized controlled trial found that patients with oral Candida infections who were supplemented with cinnamon for 15 days experienced a significant clinical improvement in their signs and symptoms [8].
• Chamomile (flowers) – Chamomile possesses several compounds that aid in defense against Candida, including caprylic acid and quercetin. In patients with inflammatory gastrointestinal conditions, researchers found that patients who took supplements containing chamomile experienced significantly reduced symptoms such as gastrointestinal irritation and diarrhea [9].
• Ginger (rhizome) – Ginger contains compounds, including shagelol and gingerol, that exhibit fungus inhibiting properties that can target Candida One study found that patients with vaginal Candida infections who were supplemented with a prescription and ginger for seven days experienced significantly improved itching, burning, and discharge quality, when compared with the prescription alone [10].
• Pau D’ Arco (bark extract) – Extracted from the Tabebuia trees within the South American rainforests, this extract contains potent compounds like quercetin and naphthoquinones. Researchers have found that the Pau D’ Arco bark extract possesses significantly higher activity against fungi and yeasts, including Candida albicans, when compared with 13 other South American traditional botanicals [11]. This extract also contains properties that influence the production of prostaglandins to balance inflammation.
• Rosemary (aerial part extract) – Rosemary, which contains a milieu of potent antioxidants, has been used for centuries across several cultures as a medicinal herb with antiseptic properties. In vitro studies show that rosemary extract exhibits inhibitory activity over Candida albicans [12]. The antioxidants within rosemary also support inflammatory balance, immune maintenance, and cognitive health.
• Biotin – Also known as vitamin B7, biotin is essential for a wide variety of metabolic processes that sustain your metabolism, immunity, and skin health, among its many other benefits. This macronutrient is needed to effectively neutralize reactive oxygen species and support T-cell and B-cell mediated immunity. These defense mechanisms are critical when defending against Candida

References

1. Bhattacharyya A, Sinha M, Singh H, et al. Mechanistic Insight Into the Antifungal Effects of a Fatty Acid Derivative Against Drug-Resistant Fungal Infections. Front Microbiol. 2020;11:2116. Published 2020 Sep 8. doi:10.3389/fmicb.2020.02116
2. Rosenblatt J, Reitzel RA, Vargas-Cruz N, Chaftari AM, Hachem R, Raad I. Caprylic and Polygalacturonic Acid Combinations for Eradication of Microbial Organisms Embedded in Biofilm. Front Microbiol. 2017;8:1999. Published 2017 Oct 18. doi:10.3389/fmicb.2017.01999
3. Hoshimoto A, Suzuki Y, Katsuno T, Nakajima H, Saito Y. Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. Br J Pharmacol. 2002;136(2):280-286. doi:10.1038/sj.bjp.0704719
4. Tan, W., Li, Y., Chen, M., & Wang, Y. (2011). Berberine hydrochloride: anticancer activity and nanoparticulate delivery system. International journal of nanomedicine, 6, 1773–1777. https://doi.org/10.2147/IJN.S22683
5. Li, De-Dong et al. “Fluconazole assists berberine to kill fluconazole-resistant Candida albicans.” Antimicrobial agents and chemotherapy vol. 57,12 (2013): 6016-27. doi:10.1128/AAC.00499-13
6. Manohar V, Ingram C, Gray J, et al. Antifungal activities of origanum oil against Candida albicans. Mol Cell Biochem. 2001;228(1-2):111-117. doi:10.1023/a:1013311632207
7. Wang GS, Deng JH, Ma YH, Shi M, Li B. Mechanisms, clinically curative effects, and antifungal activities of cinnamon oil and pogostemon oil complex against three species of Candida. J Tradit Chin Med. 2012;32(1):19-24. doi:10.1016/s0254-6272(12)60026-0
8. de Araújo MRC, Maciel PP, Castellano LRC, et al. Efficacy of essential oil of cinnamon for the treatment of oral candidiasis: A randomized trial. Spec Care Dentist. 2021;41(3):349-357. doi:10.1111/scd.12570
9. Albrecht U, Müller V, Schneider B, Stange R. Efficacy and safety of a herbal medicinal product containing myrrh, chamomile and coffee charcoal for the treatment of gastrointestinal disorders: a non-interventional study. BMJ Open Gastroenterol. 2015;1(1):e000015. Published 2015 Feb 6. doi:10.1136/bmjgast-2014-000015
10. Shabanian S, Khalili S, Lorigooini Z, Malekpour A, Heidari-Soureshjani S. The effect of vaginal cream containing ginger in users of clotrimazole vaginal cream on vaginal candidiasis. J Adv Pharm Technol Res. 2017;8(2):80-84. doi:10.4103/japtr.JAPTR_176_16
11. Portillo A, Vila R, Freixa B, Adzet T, Cañigueral S. Antifungal activity of Paraguayan plants used in traditional medicine. J Ethnopharmacol. 2001;76(1):93-98. doi:10.1016/s0378-8741(01)00214-8
12. Saeidi S, Forgani F, Javadian F, Javadian E. Effects of Rosmarinus Officinalis Plant Extract on Trichomonas Vaginalis Parasites and Candida albicans under Laboratory Conditions: An Experimental Study, Gene Cell Tissue. 2019; 6(3):e92867.